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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: Jun 8, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Inflammatory bowel disease and asthma: a population-based, case-control study.

Yilma A Fenta1, Natalia Tello, Ji A Jung

  • 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Inflammatory Bowel Diseases
|September 18, 2010
PubMed
Summary

This study found that asthma, a T-helper 2 (Th2) condition, does not reduce the risk of inflammatory bowel disease (IBD), a Th1 condition. Further research is needed to fully understand the asthma-IBD association.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Epidemiology

Background:

  • Previous studies suggest a potential link between asthma and an increased risk of inflammatory bowel disease (IBD).
  • Asthma is characterized as a T-helper 2 (Th2) immune response, while IBD is considered a T-helper 1 (Th1) condition.

Purpose of the Study:

  • To investigate whether asthma, as a Th2-dominant condition, confers a reduced risk of developing IBD, a Th1-dominant condition.
  • To examine the association between asthma and IBD using a population-based, case-control study design.

Main Methods:

  • A population-based, case-control study was conducted in Rochester, Minnesota, from 1964 to 1983.
  • Inclusion criteria for IBD and asthma were predetermined.
  • Cases with IBD were matched 1:1 with controls based on age and gender, with controls randomly selected from the community.

Main Results:

  • The study included 231 IBD cases (55% ulcerative colitis, 45% Crohn's disease) and matched controls.
  • A small percentage of IBD cases (1.7%) and controls (0.9%) had a history of asthma prior to the IBD diagnosis.
  • No statistically significant association was found between prior asthma diagnosis and the risk of developing IBD (unadjusted OR: 3.0, P=0.34).
  • Ever having asthma was also not significantly associated with IBD risk (unadjusted OR: 1.4, P=0.40).

Conclusions:

  • The findings indicate that asthma, as a Th2 condition, does not appear to reduce the risk of IBD, a Th1 condition.
  • Limitations in the current study and existing literature necessitate further investigation into the complex relationship between asthma and IBD.