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Updated: Jun 8, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer
1Divisions of Gastroenterology and Hepatology, VA North Texas Health Care System, and University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. LindaA.Feagins@va.gov
Abstract:
Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut.
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