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Updated: Jun 8, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
[Design and synthesis of novel PPARgamma agonists]
1Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Objective:
To design and synthesize novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.
Methods:
A series of novel PPARgamma agonists were designed based on the binding character of PPARgamma agonists and the distribution of pharmacophore. The target compounds were synthesized using p-hydroxybenzaldehyde, 1, 2-dibromoethane, phenol, hydantoin and 2-thiohydantoin as materials.
Results:
Twelve compounds were synthesized by etherification and Knoevenagle condensation.
Conclusion:
The target compounds were efficiently synthesized under mild condition and the structures of the target compounds were confirmed by 1HNMR and MS.
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