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Mid term results after bone marrow laser revascularization for treating refractory angina
Guillermo Reyes1, Keith B Allen, Pablo Alvarez
1Department of Cardiovascular Surgery, Hospital Universitario La Princesa, Madrid 28006, Spain. guillermo_reyes_copa@yahoo.es
Transmyocardial revascularization combined with autologous stem cell therapy significantly improved angina class and reduced medication use in patients with diffuse coronary artery disease. This combined therapy showed midterm clinical benefits without adverse events or left ventricular morphological changes.
Area of Science:
- Cardiology
- Regenerative Medicine
- Surgical Innovation
Background:
- Diffuse coronary artery disease presents a significant therapeutic challenge.
- Medically refractory angina class III/IV necessitates advanced treatment strategies.
- Transmyocardial revascularization (TMR) and stem cell therapy are emerging options.
Purpose of the Study:
- To evaluate midterm outcomes of TMR combined with autologous stem cell therapy.
- To assess the safety and efficacy of this combined approach in patients with diffuse coronary artery disease.
- To analyze changes in angina class, medication usage, and cardiac hospital readmissions.
Main Methods:
- Nineteen patients with refractory angina received TMR and intramyocardial stem cell injection.
- Autologous bone marrow was aspirated and processed for stem cell isolation.
- Cardiac MRI and isotopic tests were performed pre- and post-procedure with clinical follow-up.
Main Results:
- No perioperative adverse events or arrhythmias were observed.
- Significant improvement in angina class (3.4 to 1.4) and reduced medication use (p=0.001).
- Reduced cardiac hospital readmissions (p<0.001) and a 3% ejection fraction improvement noted on MRI.
Conclusions:
- The TMR/stem cell combination delivery was safe and effective.
- Midterm follow-up demonstrated significant clinical improvement in patients.
- No adverse morphological changes in the left ventricle were observed post-procedure.
