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Transsphenoidal hypophysectomy: a critical review.

M B Siegel1, R A Hendrix

  • 1Department of Otolaryngology and Human Communication, Hospital of the University of Pennsylvania, Philadelphia 19104.

Transactions - Pennsylvania Academy of Ophthalmology and Otolaryngology
|January 1, 1990
PubMed
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Surgical approaches to pituitary tumors, especially prolactinomas, have evolved. Transsphenoidal hypophysectomy is standard, but alternative sinonasal techniques may reduce morbidity compared to the sublabial approach.

Area of Science:

  • Neurosurgery
  • Otolaryngology
  • Endocrinology

Background:

  • Pituitary tumor resection has evolved significantly over the last century.
  • Prolactinomas are the most frequent reason for hypophysectomy (pituitary gland removal).
  • Transsphenoidal hypophysectomy is the current standard for accessing the pituitary fossa.

Purpose of the Study:

  • To review the historical changes and current trends in surgical approaches for pituitary tumors.
  • To highlight the importance of sinonasal anatomy in transsphenoidal surgery.
  • To compare the morbidity associated with different surgical access techniques.

Main Methods:

  • Review of historical and contemporary surgical techniques for pituitary tumor resection.
  • Emphasis on transsphenoidal approaches and their anatomical considerations.

Related Experiment Videos

  • Discussion of alternative sinonasal access routes versus the traditional sublabial approach.

    • Main Results:

    • Transsphenoidal hypophysectomy is the established surgical standard.
    • Knowledge of sinonasal anatomy is crucial for successful transsphenoidal procedures.
    • Alternative techniques may offer reduced morbidity compared to the sublabial approach.

    Conclusions:

    • Surgical strategies for pituitary tumors continue to advance.
    • Otolaryngologic expertise is valuable for optimizing transsphenoidal pituitary surgery.
    • Minimizing morbidity through alternative surgical approaches is a key development.