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Technical factors that influence neural transplant safety in Huntington's disease

T B Freeman1, F Cicchetti, A C Bachoud-Lévi

  • 1Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33606-3571, USA. tfreeman@health.usf.edu

Experimental Neurology
|September 21, 2010
PubMed
Abstract

No abstract available in PubMed .

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

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