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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
09:50

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

[Secondary limb lymphedema].

Stéphane Vignes1

  • 1Hôpital Cognacq-Jay, Centre national de référence des maladies vasculaires rares, unité de lymphologie, 75015 Paris, France. stephane.vignes@hopital-cognacq-jay.fr

Presse Medicale (Paris, France : 1983)
|September 21, 2010
PubMed
Summary
This summary is machine-generated.

Lymphedema, a condition of lymphatic swelling, arises from congenital issues or acquired causes like cancer treatments and infections. Early diagnosis is crucial to rule out serious conditions like deep vein thrombosis or cancer recurrence.

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A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

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Last Updated: Jun 8, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
09:50

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Area of Science:

  • Medicine
  • Oncology
  • Vascular Biology

Context:

  • Lymphedema encompasses primary (congenital) and secondary (acquired) forms stemming from lymphatic system damage.
  • Secondary lymphedema is prevalent post-breast cancer treatment in France, while lymphatic filariasis is the leading global cause.
  • Cancer treatments involving lymph node excision and radiotherapy frequently lead to secondary lymphedema.

Purpose:

  • To delineate the diverse etiologies of lymphedema, focusing on primary and secondary causes.
  • To highlight the significant impact of cancer treatments on secondary lymphedema development.
  • To emphasize the importance of investigating deep venous thrombosis and cancer recurrence at lymphedema onset.

Summary:

  • Lymphedema results from lymphatic abnormalities, with secondary forms common after cancer therapy (e.g., breast cancer surgery and radiation).
  • Lymphatic filariasis is the primary global cause, while cancer treatments are major contributors to secondary lymphedema.
  • Differential diagnosis at onset should include deep venous thrombosis and cancer recurrence, with rare causes like rheumatic diseases also considered.

Impact:

  • Provides a comprehensive overview of lymphedema causes, aiding clinicians in diagnosis and management.
  • Enhances understanding of lymphedema as a significant adverse effect of cancer treatment.
  • Underscores the need for vigilance regarding serious underlying conditions when lymphedema presents.