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A hip analysis protocol for pediatric bone densitometry: the Iowa Bone Development Study.

Julie M Eichenberger Gilmore1, Cynthia A Pauley, Trudy L Burns

  • 1Department of Preventive and Community Dentistry, The University of Iowa, Iowa City, IA, USA. julie-gilmore@uiowa.edu

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|September 21, 2010
PubMed
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A new protocol for pediatric proximal femur dual-energy X-ray absorptiometry (DXA) scans improves analysis stability and alignment with body size. This method offers a reproducible approach for evaluating bone density in growing children.

Area of Science:

  • Pediatric Endocrinology
  • Bone Densitometry
  • Medical Imaging Analysis

Background:

  • Pediatric proximal femur dual-energy X-ray absorptiometry (DXA) analysis faces challenges due to the evolving pediatric skeleton.
  • Lack of standardized reference points complicates accurate bone density measurements in children.

Purpose of the Study:

  • To develop and validate a modified, pediatric-specific proximal femur analysis protocol for DXA scans.
  • To improve the precision and reliability of bone densitometry in growing pediatric populations.

Main Methods:

  • The Iowa Bone Development Study (IBDS) created a custom Hologic software protocol for pediatric proximal femur DXA analysis.
  • Serial DXA measurements were collected from 214 children aged 5, 8, 11, and 13 years.
  • The IBDS protocol was compared against standard manufacturer (Hologic default) analysis procedures.

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Main Results:

  • The IBDS protocol produced lower, more stable bone area, bone mineral content (BMC), and bone mineral density (BMD) results.
  • The modified protocol demonstrated better alignment with body size, indicated by higher coefficients of determination (R(2)).
  • Spearman correlation coefficients for BMC and bone area were consistently higher with the IBDS protocol, especially in younger children.

Conclusions:

  • The IBDS pediatric-specific proximal femur analysis protocol offers a reproducible method for evaluating DXA scans in children.
  • This validated protocol enhances the accuracy and consistency of bone density assessments during childhood growth.
  • The improved methodology facilitates better tracking of bone development and potential interventions in pediatric populations.