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Updated: Jun 8, 2026

Isolation and Culture of Endothelial Cells from the Embryonic Forebrain

Isolation and Culture of Endothelial Cells from the Embryonic Forebrain

Published on: January 23, 2014

From the vascular microenvironment to neurogenesis.

Xi-Tao Yang¹, Yong-Yan Bi, Dong-Fu Feng

¹Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, China.

Brain Research Bulletin

|September 21, 2010

Summary

The adult mammalian central nervous system (CNS) repairs itself through blood vessel formation (angiogenesis) and new neuron growth (neurogenesis). The vascular microenvironment is key to regulating neural progenitor cell activity and promoting CNS repair.

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Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Published on: July 19, 2007

Area of Science:

Neuroscience
Vascular Biology
Regenerative Medicine

Background:

Adult mammalian central nervous system (CNS) repair involves angiogenesis and neurogenesis.
Neural progenitor cells (NPCs) are crucial for CNS repair and regeneration.
The neural stem cell niche contains various components that regulate NPC behavior.

Purpose of the Study:

To review the role of the vascular microenvironment in promoting neurogenesis.
To highlight how vascular components influence neural progenitor cell proliferation, differentiation, and migration.

Main Methods:

Mini-review of existing literature.
Analysis of the interactions between vascular microenvironment and neural progenitor cells.
Synthesis of information on paracrine signaling from vascular factors.

Main Results:

Vascular endothelial cells (VECs) directly influence NPC behavior through cell-cell contact.
Extracellular components within the vascular niche modulate NPC functions.
Soluble factors released by the vascular system enhance neurogenesis via paracrine signaling.

Conclusions:

The vascular microenvironment is a critical mediator of neurogenesis in the adult CNS.
Understanding these interactions can lead to novel therapeutic strategies for CNS repair.
Targeting the vascular niche holds promise for enhancing regenerative processes in the brain.