Related Experiment Video
Updated: Jun 8, 2026
05:50
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
Published on: June 2, 2023
Tissue reaction to silver nanoparticles dispersion as an alternative irrigating solution
João Eduardo Gomes-Filho1, Fernando Oliveira Silva, Simone Watanabe
1Department of Endodontics, Araçatuba School of Dentistry, Univ. Estadual Paulista, Araçatuba, SP, Brazil. joao@foa.unesp.br
Journal of Endodontics
|September 21, 2010
Summary
Silver nanoparticles dispersion in fibrin sponge showed biocompatibility in rat tissue implants. Lower concentrations of silver nanoparticles exhibited better tissue integration, indicating potential for biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Tissue Engineering
Background:
- Nanomaterials offer novel applications in life sciences and biotechnology.
- Silver nanoparticles (AgNPs) are explored for their antimicrobial and biocompatible properties.
- Evaluating tissue response to AgNP-embedded materials is crucial for biomedical use.
Purpose of the Study:
- To assess the tissue reaction to polyethylene tubes containing fibrin sponge with embedded silver nanoparticles dispersion.
- To compare the biocompatibility of different concentrations of AgNPs and a control.
Main Methods:
- Polyethylene tubes with fibrin sponge containing 47 ppm, 23 ppm AgNPs, or sodium hypochlorite were implanted in rats.
- Tissue response was evaluated at 7, 15, 30, 60, and 90 days post-implantation.
- Histological analysis using hematoxylin-eosin staining assessed qualitative and quantitative tissue reactions.
Main Results:
- Moderate tissue reactions were observed at 7 days for both AgNP concentrations.
- Tissue response normalized to control levels by day 15 for 23 ppm AgNPs and day 30 for 47 ppm AgNPs.
- AgNP dispersion demonstrated a concentration-dependent biocompatibility profile.
Conclusions:
- Silver nanoparticles dispersion is biocompatible, particularly at lower concentrations.
- AgNP-embedded materials show promise for biomedical applications requiring tissue integration.
- Further research can optimize AgNP concentrations for enhanced biocompatibility.
Related Concept Videos
01:09Colloidal precipitates
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
01:21Precipitation Titration Curve: Analysis
The precipitation titration curve demonstrates the change in concentration of one reactant with the volume of titrant added. During the titration of chloride ions with silver nitrate, the precipitation titration curve is divided into three regions: before, at, and after the equivalence point. Before the equivalence point, low redissolution of the sparingly soluble silver chloride precipitate gives a low silver ion concentration. However, in the second region, representing the equivalence point,...
03:45Formation of Complex Ions
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...