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Aberrant expression of the pluripotency marker SOX-2 in endometriosis
Martin Götte1, Maria Wolf, Annette Staebler
1Department of Gynecology and Obstetrics, University of Münster, Medical Center, Münster, Germany. martingotte@uni-muenster.de
Abstract:
Expression of the pluripotency factors SOX-2, OCT-4, KLF-4, and NANOG was analyzed by quantitative real-time polymerase chain reaction, immunohistochemistry, and immunofluorescence microscopy in the endometrium, myometrium, and endometriotic tissue of 36 patients. Aberrant expression of SOX-2 may indicate a stem cell origin of endometriosis, whereas the presence of all progenitor markers in endometrial tissue marks the endometrium as a potential source for induced pluripotent stem cell generation.
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