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Updated: Jun 8, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Particular aspects in patients with coronary heart disease and vascular cognitive impairment
Ovidiu Bajenaru1, Florina Antochi, Cristina Tiu
1University of Medicine and Pharmacy Carol Davila Bucharest, Romania. ovalbajenaru@xnet.ro
Insights
Cognitive impairment can mask severe heart disease and brain vessel issues. Early cardiovascular checks are crucial for patients with dementia to prevent unexpected cardiac death.
Area of Science:
- Neurology
- Cardiology
- Geriatrics
Background:
- Cognitive vascular impairment presents unique challenges, especially when combined with coronary heart disease (CHD).
- Some patients exhibit cognitive decline and psychiatric symptoms masking underlying cardiovascular and cerebrovascular conditions.
- Undiagnosed severe cardiovascular disease in these patients can lead to a poor prognosis and unexpected mortality.
Purpose of the Study:
- To highlight the importance of systematic cardiovascular examination in patients diagnosed with cognitive impairment or dementia.
- To identify severe, often silent, cardiovascular disorders in patients presenting with cognitive decline.
- To emphasize the risk of misdiagnosis and adverse outcomes due to masked cardiac and cerebrovascular diseases.
Main Methods:
- Systematic cardiovascular examination was performed on hospitalized patients diagnosed with dementia or cognitive impairment.
- Patients included those with and without prior diagnoses of cerebrovascular or coronary heart disease.
- Clinical history and physical examination focused on identifying silent cardiovascular and cerebrovascular disorders.
Main Results:
- Many patients with cognitive impairment had severe, undiagnosed coronary heart disease (CHD) and significant large vessel disease in the brain.
- Cognitive and psychiatric symptoms often masked serious underlying cardio- and cerebrovascular conditions.
- Lack of recognition of cardiovascular disease contributed to severe outcomes, including unexpected death.
Conclusions:
- Progressive cognitive impairment can mask severe cardiovascular and cerebrovascular disorders.
- Systematic cardiovascular assessment is vital for patients with dementia or cognitive impairment, irrespective of prior cardiac history.
- Early detection and management of cardiovascular disease are critical to prevent severe complications and unexpected mortality in this population.
Abstract:
Among the patients with cognitive vascular impairment, a particular group is represented by those who have concomitant cerebrovascular and coronary heart disease (CHD). The clinical evolution of some of these patients is dominated apparently by the progressive cognitive impairment and sometimes psychotic episodes and not by evident clinical stroke and/or symptoms of their heart disease, so that they receive the diagnosis of Alzheimer's disease or of a psychiatric disease. Most of these patients have a severe evolution, particularly if their cardiovascular disease is not recognized and die unexpectedly. In the author's clinical experience, the systematic cardiovascular examination in all patients hospitalized with the diagnosis of dementia or cognitive impairment, even if they did not have previously been diagnosed with cerebrovascular and/or coronary heart disease, disclosed in many instances the presence of severe but apparently silent cardiovascular disorders characterized always by concomitant severe CHD and significant large vessel disease of the brain. It is important to emphasize the particular situation in which the progressive cognitive impairment associated or not with psychiatric manifestations could mask severe cardio- and cerebrovascular disorders, which could further be worsened by symptomatic psychiatric treatment, and which evolution is to "unexpected" cardiovascular death.
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