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Updated: Jun 8, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Prostatic involution after intraprostatic injection of cobra toxin.

Adam M Becker1, Rick W Keck, Daniel S Murtagh

  • 1University of Toledo Health Sciences Campus, Toledo, Ohio, USA.

The Journal of Urology
|September 21, 2010
PubMed
Summary

Cobra cardiotoxin D injection in rats caused greater prostate shrinkage than botulinum toxin A, with no systemic effects. Cardiotoxin D also reduced cell proliferation, suggesting a prolonged effect on prostate structure.

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Area of Science:

  • Urology
  • Toxicology
  • Cell Biology

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Current treatments for BPH have limitations and side effects.
  • Novel therapeutic agents for prostate conditions are under investigation.

Purpose of the Study:

  • To compare the effects of intraprostatic cobra cardiotoxin D and botulinum toxin type A on prostate structure in a rat model.
  • To evaluate the potential of cardiotoxin D as a treatment for prostate conditions.

Main Methods:

  • 18 Sprague-Dawley rats were divided into three groups (n=6 each).
  • Groups received intraprostatic injections of saline, botulinum toxin type A, or cobra cardiotoxin D.
  • Prostate glands were analyzed after 14 days for weight, histology, apoptosis, and cell proliferation.

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Main Results:

  • Cardiotoxin D significantly reduced prostate weight compared to botulinum toxin A and saline controls.
  • Both cardiotoxin D and botulinum toxin A induced prostatic atrophy and increased apoptotic cells.
  • Botulinum toxin A increased proliferating cells, while cardiotoxin D did not, and only botulinum toxin A caused body weight loss.

Conclusions:

  • Intraprostatic cobra cardiotoxin D induces significant prostatic atrophy and weight reduction.
  • Cardiotoxin D demonstrates a greater effect on prostate weight reduction than botulinum toxin A.
  • Cardiotoxin D shows no systemic effects and may have a prolonged impact on prostate cell proliferation.