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Related Experiment Video

Updated: Jun 8, 2026

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

Polypoidal choroidal vasculopathy: a review.

Yutaka Imamura¹, Michael Engelbert, Tomohiro Iida

¹The LuEster T. Mertz Retinal Research Center, Manhattan Eye Ear and Throat Hospital, New York, New York, USA.

Survey of Ophthalmology

|September 21, 2010

Summary

This summary is machine-generated.

Polypoidal choroidal vasculopathy (PCV) is a hemorrhagic macular disorder primarily affecting pigmented races but also seen in whites. Advanced imaging techniques improve diagnosis and understanding of this neovascular condition.

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Area of Science:

Ophthalmology
Vascular Biology

Background:

Polypoidal choroidal vasculopathy (PCV) was first described in 1982 as a macular hemorrhagic disorder.
PCV is a significant cause of neovascular maculopathy, especially in individuals of Asian and African American descent.

Purpose of the Study:

To review the current understanding of PCV, encompassing its genetic and histopathological underpinnings.
To highlight the diagnostic advancements and clinical features distinguishing PCV from other choroidal vascular proliferations.

Main Methods:

Review of existing literature on PCV.
Emphasis on multimodal ophthalmic imaging, including indocyanine green angiography, fluorescein angiography, and optical coherence tomography.

Main Results:

PCV presents a spectrum of clinical manifestations and affects diverse populations, including white patients.
Indocyanine green angiography has proven crucial for reliable detection of PCV's characteristic vascular abnormalities.
Multimodal imaging aids in differentiating PCV from typical choroidal neovascularization.

Conclusions:

PCV is a distinct neovascular entity with a broad clinical spectrum and demographic distribution.
Enhanced diagnostic capabilities through advanced imaging have deepened the understanding of PCV's pathology and clinical course.