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Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
Cholera01:25

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Related Experiment Video

Updated: Jun 8, 2026

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

Genomic evolution of Vibrio cholerae.

Yong-Joon Cho1, Hana Yi, Je Hee Lee

  • 1School of Biological Sciences and Institute of Microbiology, Seoul National University, Gwanak 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.

Current Opinion in Microbiology
|September 21, 2010
PubMed
Summary

Genomic studies reveal that Vibrio cholerae, the cause of cholera, has a large mobilome. Mobile genomic islands differentiate pandemic strains, making traditional markers unreliable.

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TransFLP — A Method to Genetically Modify Vibrio cholerae Based on Natural Transformation and FLP-recombination
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Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
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Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

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Last Updated: Jun 8, 2026

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

TransFLP — A Method to Genetically Modify Vibrio cholerae Based on Natural Transformation and FLP-recombination
12:13

TransFLP — A Method to Genetically Modify Vibrio cholerae Based on Natural Transformation and FLP-recombination

Published on: October 8, 2012

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • Vibrio cholerae is the causative agent of cholera and an aquatic inhabitant.
  • The seventh cholera pandemic is associated with O1 El Tor biotype and O139 serogroups.
  • Recent decades show shifts in pandemic clones in Asia and Africa.

Purpose of the Study:

  • To investigate the genomic landscape of Vibrio cholerae pandemic strains.
  • To understand the role of the mobilome in V. cholerae evolution and pathogenicity.
  • To assess the reliability of traditional diagnostic markers in light of genomic diversity.

Main Methods:

  • Comparative genomic studies of V. cholerae isolates.
  • Analysis of mobile genomic islands (mobilome).
  • Genomic sequence comparison of seventh pandemic isolates.

Main Results:

  • Identification of a large mobilome in V. cholerae.
  • Seventh pandemic isolates share highly related genome sequences.
  • Genomic islands differentiate between seventh pandemic isolates.
  • Extensive lateral gene transfer observed.

Conclusions:

  • Traditional diagnostic markers like serotype and biotype are becoming unreliable for V. cholerae.
  • Genomic sequence-based methods are required for accurate diagnosis and strain differentiation.
  • The mobilome plays a significant role in the evolution of pandemic V. cholerae strains.