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Antipsychotic Drugs: Typical and Atypical Agents

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Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...

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Related Experiment Video

Updated: Jun 8, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

Risperidone induced stuttering.

Devender Singh Yadav¹

¹Department of Psychiatry, ABU University Local Health Board, Coity Clinic, P.O.W. Hospital, Bridgend, Wales CF31 1RQ, UK. dsyadav@doctors.org.uk

General Hospital Psychiatry

|September 21, 2010

Summary

This summary is machine-generated.

Antipsychotic medications can rarely cause stuttering. This report details a case of risperidone-induced stuttering, highlighting the need for further research into this uncommon side effect.

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Antipsychotic medications are widely used for treating psychosis and mania.
Stuttering is a recognized but rare side effect of some antipsychotics.
Risperidone is a common atypical antipsychotic with limited documented cases of induced stuttering.

Observation:

This report describes a new case of stuttering potentially induced by risperidone.
The patient developed stuttering during treatment with risperidone.
This adds to the very limited existing literature on risperidone-induced stuttering.

Findings:

Antipsychotic-induced stuttering is an uncommon adverse drug reaction.
Risperidone, while generally well-tolerated, may rarely cause stuttering.
Diagnosis requires a high index of suspicion due to the rarity of this side effect.

Implications:

Further research is needed to understand the neurophysiological mechanisms of adult-onset stuttering.
Investigating the specific pathways involved in risperidone-induced stuttering is crucial.
Enhanced awareness among clinicians may improve diagnosis and management of this rare side effect.