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Updated: Jun 8, 2026

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Heterobifunctional PEGs: efficient synthetic strategies and useful conjugation methodologies
Daniel E Levy1, Brian Frederick, Bing Luo
1Intradigm Corporation, 3350 West Bayshore Road, Suite 100, Palo Alto, CA 94303, United States. del345@gmail.com
Abstract:
The desire to develop nanoparticle and liposomal formulations as drug carriers capitalizing on active transport mechanisms requires constant development of novel heterobifunctional polyethyleneglycol (PEG) constructs. Such constructs should be capable of sequentially reacting with extracellular binding ligands and structural components of nanoparticles and/or liposomes. This paper describes two syntheses of heterobifunctional PEGs useful for tethering small molecule ligands to synthetic lysine-bearing polymers.
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