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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method

Nareerat Kitisripanya1, Pachareenart Saparpakorn, Peter Wolschann

  • 1Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand.

Nanomedicine : Nanotechnology, Biology, and Medicine
|September 21, 2010
PubMed

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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