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Studies on scavenger receptors under experimental hypercholesterolemia: modulation on selenium supplementation
Harmandeep Kaur1, Mohinder P Bansal
1Department of Biophysics, Panjab University, Chandigarh 160014, India.
Biological Trace Element Research
|September 21, 2010
Summary
Selenium supplementation may reduce atherosclerosis by modulating scavenger receptors. This study found selenium decreased harmful CD36 receptor expression in hypercholesterolemic rats, suggesting a potential therapeutic role.
Area of Science:
- Biochemistry
- Cardiovascular Research
- Nutritional Science
Background:
- Scavenger receptors (SR) bind modified lipoproteins, influencing foam cell formation in atherosclerosis.
- Oxidized low-density lipoprotein (ox-LDL) plays a key role in atherogenesis, implicating SR in disease pathogenesis.
Purpose of the Study:
- To investigate the effect of selenium (Se) supplementation on scavenger receptor SRB1 and CD36 expression in experimental hypercholesterolemia.
Main Methods:
- Rats were fed control, high cholesterol (HCD), or HCD + Se diets for 4 months.
- Serum selenium and liver reactive oxygen species (ROS) were measured.
- SRB1 and CD36 mRNA and protein expression were analyzed using RT-PCR and ELISA.
Main Results:
- Hypercholesterolemia decreased selenium levels and increased ROS.
- Selenium supplementation reduced ROS levels.
- HCD reduced SRB1 protein expression, while selenium supplementation decreased HCD-induced CD36 mRNA and protein expression.
Conclusions:
- CD36 receptors appear to promote atherosclerosis in hypercholesterolemia.
- Selenium supplementation may offer a therapeutic strategy to mitigate hypercholesterolemia's adverse effects.
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