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Related Concept Videos

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Related Experiment Video

Updated: Jun 8, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

Assessment of splenic function.

A P N A de Porto1, A J J Lammers, R J Bennink

  • 1Department of Infectious Diseases, Tropical Medicine and AIDS, G2-105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. alexander.deporto@student.uva.nl

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|September 21, 2010
PubMed
Summary
This summary is machine-generated.

Hyposplenic patients face a high risk of overwhelming post-splenectomy infection (OPSI). Assessing splenic function is crucial for prevention, with pitted erythrocytes and scintigraphy being key diagnostic methods.

Related Experiment Videos

Last Updated: Jun 8, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

Area of Science:

  • Immunology
  • Hematology
  • Nuclear Medicine

Background:

  • Hyposplenic patients are susceptible to overwhelming post-splenectomy infection (OPSI), a condition with high mortality.
  • Accurate identification of patients with diminished splenic function is challenging.
  • Preventive strategies necessitate reliable methods for assessing spleen function.

Purpose of the Study:

  • To review immunological, hematological, and scintigraphic parameters for measuring splenic function.
  • To evaluate the efficacy of different methods in identifying patients at risk of OPSI.

Main Methods:

  • Discussion of immunological markers, including IgM memory B cells.
  • Evaluation of hematological parameters such as Howell-Jolly bodies and pitted erythrocytes.
  • Assessment of scintigraphic techniques, specifically (99m)Tc-labelled erythrocyte scintigraphy with SPECT-CT.

Main Results:

  • IgM memory B cells require further validation as a splenic function parameter.
  • Howell-Jolly bodies are not accurate indicators of splenic function.
  • The percentage of pitted erythrocytes is a well-evaluated, suitable first-line investigation.
  • (99m)Tc-labelled erythrocyte scintigraphy with SPECT-CT provides a comprehensive assessment of splenic function.

Conclusions:

  • Scintigraphy is the most reliable method but impractical for large-scale screening.
  • Percentage of pitted erythrocytes is recommended as a suboptimal but practical first-line test.
  • Abnormal pitted erythrocyte results should be confirmed with scintigraphy.
  • Further research is needed for novel splenic function markers.