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Harderian gland tumours in mice
1Department of Pathology, Huntingdon Research Centre, Cambs, England.
Arzneimittel-Forschung
|November 1, 1990
Summary
Harderian gland tumors occurred more often in male mice than female mice. Metastasis was observed in lymph nodes, lungs, and other organs, with fat vacuolation aiding diagnosis.
Area of Science:
- Oncology
- Veterinary Pathology
- Rodent Toxicology
Background:
- Harderian glands are accessory orbital glands found in many vertebrates, including rodents.
- Tumors of the Harderian gland are relatively uncommon but can occur in laboratory animals.
- Understanding the incidence and characteristics of these tumors is important for interpreting toxicity studies.
Purpose of the Study:
- To survey the occurrence and characteristics of Harderian gland tumors in control CD-1 mice.
- To identify any sex-based differences in tumor incidence.
- To document metastatic patterns and diagnostic features.
Main Methods:
- Histopathological examination of Harderian glands from 3302 untreated CD-1 mice.
- Analysis of tumor incidence based on sex.
- Documentation of tumor type, pigment presence, metastasis, and diagnostic features.
Main Results:
- A higher incidence of Harderian gland adenomas was observed in males (5%) compared to females (2%).
- No significant sex difference was noted for Harderian gland carcinomas.
- Metastasis of carcinomas occurred in lymph nodes, lungs, thymus, and liver. Porphyrin pigment was present in some tumors.
- Fat vacuolation was identified as a useful diagnostic feature.
Conclusions:
- Male CD-1 mice exhibit a higher incidence of Harderian gland adenomas than females.
- Harderian gland tumors can metastasize, requiring thorough examination for accurate staging.
- Fat vacuolation is a key diagnostic indicator for Harderian gland tumors.