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Dendritic cells in cancer immunotherapy

Gerold Schuler1

  • 1Department of Dermatology, University Hospital Erlangen, Erlangen, Germany. gerold.schuler@uk-erlangen.de

European Journal of Immunology
|September 21, 2010
PubMed

DC initiate and regulate T-cell immunity and are thus the key to optimization of all types of vaccines. Insights into DC biology offer many opportunities to enhance immunogenicity. In this Viewpoint, I discuss some recent developments and findings that are of immediate relevance for the clinical development of cancer vaccines. In addition, I emphasize my personal view that we should explore the potential of adoptively transferred DC (i.e. DC vaccination) as cancer vaccines by performing two-armed trials that address critical variables and by delivering antigens via mRNA-transfected DC.

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