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Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
Published on: November 2, 2020
Olfactory ensheathing glia express aquaporin 1
Shannon D Shields1, Katherine D Moore, Patricia E Phelps
1Department of Anatomy and Physiology, WM Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California 94158, USA.
The Journal of Comparative Neurology
|September 21, 2010
Summary
Olfactory ensheathing glia (OEG) express aquaporin 1 (AQP1), a novel marker that helps distinguish them from other glial cells. This finding aids in understanding OEG function and potential in nerve regeneration.
Area of Science:
- Neuroscience
- Cell Biology
- Glial Cell Biology
Background:
- Olfactory ensheathing glia (OEG) possess unique properties and a restricted location in the nervous system.
- OEG are of interest for their potential role in axonal regeneration, particularly after spinal cord injury.
- Lack of specific neurochemical markers hinders the study and differentiation of OEG from other glia.
Purpose of the Study:
- To identify novel neurochemical markers for olfactory ensheathing glia (OEG).
- To investigate the expression of aquaporin 1 (AQP1) in OEG.
- To establish AQP1 as a distinguishing characteristic of OEG.
Main Methods:
- Anatomical colocalization studies were performed.
- OEG were analyzed both in vivo and in vitro.
- Expression of aquaporin 1 (AQP1) was assessed in OEG.
Main Results:
- Olfactory ensheathing glia (OEG) were found to express aquaporin 1 (AQP1).
- AQP1 expression was confirmed in OEG in both in vivo and in vitro experimental settings.
- The anatomical colocalization studies provided evidence for AQP1 as a marker for OEG.
Conclusions:
- Aquaporin 1 (AQP1) expression is a significant distinguishing characteristic of olfactory ensheathing glia (OEG).
- AQP1 may impart unique functional properties to OEG.
- Identification of AQP1 as an OEG marker facilitates further research into OEG biology and therapeutic potential.
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