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Behavioral Characterization of an Angelman Syndrome Mouse Model
Published on: October 20, 2023
Adaptive behaviour in Angelman syndrome: its profile and relationship to age
C Brun Gasca1, J E Obiols, A Bonillo
1Universitat Autonoma de Barcelona, Facultat de Psicologia, Bellaterra, Spain. carme.brun@uab.cat
Background:
Angelman syndrome (AS) is a neurodevelopmental disorder usually caused by an anomaly in the maternally inherited chromosome 15. The main features are severe intellectual disability, speech impairment, ataxia, epilepsy, sleep disorder and a behavioural phenotype that reportedly includes happy disposition, attraction to/fascination with water and hypermotoric behaviour.
Method:
We studied the level of adaptive behaviour and the adaptive behavioural profile in the areas of 'motor skills', 'language and communication', 'personal life skills' and 'community life skills' in a group of 25 individuals with genetically confirmed AS, to determine whether there is a specific adaptive behaviour profile.
Results And Conclusions:
None of the individuals, whatever their chronological age, had reached a developmental age of 3 years. A specific adaptive behaviour profile was found, with 'personal life skills' emerging as relative strengths and 'social and communication skills' as weaknesses.
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