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Related Experiment Video

Updated: Jun 8, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Optimizing ICD programming for shock reduction.

Joerg O Schwab¹

¹Department of Medicine-Cardiology, University of Bonn, Sigmund-Freud, Str. 25, 53105 Bonn, Germany. joerg.schwab@ukb.uni-bonn.de

Fundamental & Clinical Pharmacology

|September 22, 2010

Summary

This summary is machine-generated.

Prolonging implantable cardioverter-defibrillator (ICD) detection times for ventricular tachyarrhythmia (VT) significantly reduces inappropriate shocks. This improves patient quality of life and adherence to life-saving ICD therapy.

Related Experiment Videos

Last Updated: Jun 8, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Area of Science:

Cardiology
Medical Devices
Electrophysiology

Background:

Increasing use of implantable cardioverter-defibrillators (ICDs) for primary prevention (PP) highlights the issue of inappropriate therapy.
Inappropriate shocks can decrease patient adherence, reduce quality of life, and lead to anxiety or depression.

Purpose of the Study:

To evaluate the impact of prolonged detection intervals on reducing inappropriate implantable cardioverter-defibrillator (ICD) therapies.
To assess the efficacy of antitachycardia pacing and extended detection times in managing ventricular arrhythmias.

Main Methods:

Review of studies including the PainFREE Rx II, PREPARE, and RELEVANT trials.
Comparison of historical control groups with patients receiving prolonged ICD detection intervals.
Analysis of randomized controlled trials investigating extended detection settings for fast ventricular tachycardia (FVT) and ventricular tachyarrhythmia (VT).

Main Results:

Antitachycardia pacing successfully terminated fast ventricular arrhythmias (≥188 bpm) in a majority of episodes.
Extended ICD detection times significantly decreased inappropriate shocks for both supraventricular and ventricular tachyarrhythmias.
The RELEVANT study showed a significant reduction in ICD shocks and hospital admissions with increased detection time in CRT-ICD patients.

Conclusions:

Programming longer detection intervals for ventricular tachyarrhythmia (VT) is an effective strategy to reduce inappropriate implantable cardioverter-defibrillator (ICD) therapies.
Optimizing ICD detection settings can improve patient outcomes and adherence to therapy.
Ongoing trials like ADVANCE III continue to investigate optimal detection parameters for various patient populations.