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Transforming growth factor-beta inhibits lactogenic hormone induction of beta-casein expression in HC11 mouse mammary
1Department of Cell Biology, Academy of Sciences, Berlin-Buch, GDR.
Growth Factors (Chur, Switzerland)
|January 1, 1990
Abstract:
HC11 mouse mammary epithelial cells can undergo a limited functional differentiation in terms of beta-casein synthesis in response to the combined action of dexamethasone and prolactin. Transforming growth factor-beta (TGF-beta) can inhibit beta-casein expression in HC11 cells in a dose-dependent manner. This effect is reversible and specific as shown by comparison with the effect of other growth factors. TGF-beta also inhibits DNA synthesis of HC11 cells. These findings suggest a possible role of TGF-beta as an inhibitor of functional differentiation in the mammary gland.