Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome.

Science advances·2026

Same author

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome.

bioRxiv : the preprint server for biology·2025

Same author

Genetic and Pharmacological Inhibition of PAPP-A Reduces Bleomycin-Induced Pulmonary Fibrosis in Aged Mice via Reduced IGF Signaling.

Aging biology·2025

Same author

Cellular senescence and PAPP-A.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2025

Same author

The IGF System and Aging.

Endocrine reviews·2024

Same author

Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2024

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

PAPP-A: a new anti-aging target?

Cheryl A Conover¹

¹Division of Endocrinology, Metabolism, and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA. Conover.Cheryl@Mayo.edu

|September 22, 2010

Summary

Pregnancy-associated plasma protein-A (PAPP-A) influences mammalian aging. PAPP-A knockout mice offer a novel model for studying IGF

Area of Science:

Biogerontology
Molecular Biology

Background:

Pregnancy-associated plasma protein-A (PAPP-A) is an enzyme with a key role in the insulin-like growth factor (IGF) system.
Its expression is tightly regulated and influences local IGF bioavailability.

Purpose of the Study:

To review the role of PAPP-A in mammalian aging and age-related diseases.
To highlight the significance of the PAPP-A knockout (KO) mouse model in aging research.

Main Methods:

Literature review focusing on PAPP-A function, regulation, and involvement in aging.
Analysis of data from PAPP-A KO mouse studies relevant to aging and lifespan.

Main Results:

PAPP-A plays a significant role in the aging process and the development of age-related diseases.

More Related Videos

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

PAPP-A deficiency impacts IGF availability and consequently affects healthspan and lifespan.

Conclusions:

The PAPP-A KO mouse is a crucial tool for investigating how tissue-specific IGF regulation impacts aging.
Targeting PAPP-A may offer therapeutic strategies for modulating aging and age-related conditions.