Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipomatous Hamartoma of the Semilunar Valve Exhibits Molecular Genetic Characteristics of Lipoma.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
Same author

In Reply.

Archives of pathology & laboratory medicine·2026
Same author

GPNMB immunohistochemistry distinguishes diagnostically challenging cases of lymphangioleiomyomatosis from other mesenchymal neoplasms presenting with cystic lung metastases.

Human pathology·2026
Same author

Clinical and Radiologic Characteristics of Familial Pulmonary Fibrosis.

Annals of the American Thoracic Society·2026
Same author

TSC2, cathepsin K, and β-catenin as immunohistochemical markers for lymphangioleiomyomatosis.

Human pathology·2026
Same author

Novel BRAF fusion in Erdheim-Chester disease with pulmonary manifestations: Importance of RNA-based testing and response to MEK inhibition.

Histopathology·2026
Same journal

Malignant adenomyoepithelioma of the breast: seven cases illustrating morphological diversity and diagnostic challenges.

Histopathology·2026
Same journal

A CRX-positive RB1-deficient bone tumour with a retinoblastoma-like DNA methylation profile.

Histopathology·2026
Same journal

Perivascular epithelioid cell tumours of the genitourinary tract: clinicopathological features and molecular landscape.

Histopathology·2026
Same journal

Navigating diagnostic challenges in low-grade spindle cell lesions of the breast: a retrospective review.

Histopathology·2026
Same journal

Neoplastic transformation of sporadic gastric hyperplastic polyps: a systematic review and meta-analysis of risk factors and clinicopathological features.

Histopathology·2026
Same journal

KRAS-mutant serrated lesion with TSA-like dysplasia in the appendix.

Histopathology·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Desquamative interstitial pneumonia.

Henry D Tazelaar1, Joanne L Wright, Andrew Churg

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic in Arizona, Scottsdale, AZ 85050, USA. tazelaar.henry@mayo.edu

Histopathology
|September 22, 2010
PubMed
Summary
This summary is machine-generated.

Desquamative interstitial pneumonia (DIP) is a rare lung disease characterized by macrophage accumulation. While often linked to smoking, other inhaled agents can cause DIP, which has a better prognosis than related fibrotic lung diseases.

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Related Experiment Videos

Last Updated: Jun 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Area of Science:

  • Pulmonology
  • Pathology

Background:

  • Desquamative interstitial pneumonia (DIP) is a rare idiopathic interstitial pneumonia.
  • It involves significant accumulation of macrophages in alveolar spaces, often containing brown pigment ('smoker's macrophages').
  • Associated findings include interstitial inflammation, fibrosis, lymphoid nodules, and eosinophil infiltrates.

Purpose of the Study:

  • To describe the key pathological features of Desquamative interstitial pneumonia (DIP).
  • To discuss the etiology, including smoking and other inhaled agents.
  • To differentiate DIP from related lung conditions like respiratory bronchiolitis-interstitial lung disease (RB-ILD) and fibrotic non-specific interstitial pneumonia (NSIP) based on prognostic factors.

Main Methods:

  • Histopathological examination of lung tissue.
  • Clinical correlation of findings with patient history, including smoking and exposure history.
  • Comparative analysis with other interstitial lung diseases.

Main Results:

  • DIP is characterized by abundant macrophages in alveoli, often pigmented.
  • Cigarette smoking is the most common cause, but marijuana smoke and other inhaled agents can also induce DIP.
  • DIP shows distinct features from RB-ILD, and its prognosis is generally better than fibrotic NSIP, despite potential morphological overlap.

Conclusions:

  • DIP is a distinct clinicopathological entity, primarily associated with smoking.
  • Distinguishing DIP from fibrotic NSIP is crucial for accurate prognosis and management.
  • While most DIP patients respond to treatment, some may develop progressive fibrosis.