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Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Polyethylene sebacate-doxorubicin nanoparticles for hepatic targeting
Swati A Guhagarkar1, Rajiv V Gaikwad, Abdul Samad
1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, Maharashtra 400 019, India.
International Journal of Pharmaceutics
|September 22, 2010
Summary
This study developed novel polyethylene sebacate-doxorubicin nanoparticles using pullulan for targeted liver cancer therapy. These nanoparticles show potential for improved drug delivery and reduced cardiotoxicity.
Area of Science:
- * Pharmaceutical Nanotechnology
- * Drug Delivery Systems
- * Cancer Therapeutics
Background:
- * Hepatic cancer requires effective drug delivery systems.
- * Doxorubicin (DOX) is a potent chemotherapeutic agent with limitations in targeted delivery.
- * Polyethylene sebacate (PES) nanoparticles offer a potential platform for drug encapsulation.
Purpose of the Study:
- * To develop and characterize novel PES-doxorubicin nanoparticles (PES-DOX NP) for hepatic targeting.
- * To utilize pullulan as an asialoglycoprotein receptor (ASGPR) ligand for enhanced hepatocyte uptake.
- * To evaluate the in vitro and in vivo performance of the developed nanoparticles.
Main Methods:
- * Modified nanoprecipitation technique used for nanoparticle preparation with PES, Gantrez AN 119, and DOX.
- * Pullulan adsorbed onto nanoparticles (PES-DOX-PUL) to act as a ligand and stealth agent.
- * Fourier-transform infrared spectroscopy (FTIR) confirmed drug complexation; freeze-drying for stability; in vitro release studies; hemolytic potential and serum stability assays; biodistribution studies in rats using (99m)Tc labeling.
Main Results:
- * High entrapment efficiency and drug loading achieved due to intimate association and ionic complexation.
- * Zero-order kinetics observed for drug release from PES NP.
- * PES-DOX-PUL nanoparticles demonstrated low hemolytic potential and good serum stability.
- * Biodistribution studies showed prolonged circulation and reduced concentration in the heart, suggesting lower cardiotoxicity.
- * Higher blood concentration and lower liver concentration of PES-DOX-PUL confirmed long-circulating nature.
Conclusions:
- * Developed PES-DOX-PUL nanoparticles are a promising system for targeted hepatic cancer therapy.
- * Pullulan functionalization enhances nanoparticle circulation time and potential for hepatocyte targeting.
- * The system exhibits favorable safety profiles, including reduced cardiotoxicity.
- * This approach offers a simple yet effective strategy for high drug loading in nanoparticles for improved cancer treatment.
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