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[Toxicity of matrine in Kunming mice]
Xiao-yan Wang1, Lei Liang, Jian-lan Chang
1Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wangxiaoyan639@163.com
Objective:
To investigate the acute toxicity and assess the median lethal dose (LD50) of matrine in Kunming mice.
Methods:
Matrine at different doses were administered in Kunming mice via intraperitoneal injection, and the toxic reactions and LD50 of matrine was observed and determined.
Results:
The acute toxicity test of matrine indicated that the tolerable dose of matrine was above 80 mg/kg in Kunming mice, and the LD50 was 157.13 mg/kg (95%CI, 88.08-280.31 mg/kg). Morphological observation revealed degenerative changes of the nerve cells in the brain tissue of the mice.
Conclusion:
The nervous system is the main target organ by the toxicity of matrine.