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Updated: Jun 8, 2026

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
Published on: October 1, 2010
The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels
Peter Zylbergold1, Nitya Ramakrishnan, Terence Hebert
1Department of Pharmacology and Therapeutics, McGill University, Québec, Canada.
Abstract:
Kir3 channels (also known as GIRK channels) are important regulators of electrical excitability in both cardiomyocytes and neurons. Much is known regarding the assembly and function of these channels and the roles that their interacting proteins play in controlling these events. Further, they are one of the best studied effectors of heterotrimeric G proteins in general and Gβγ subunits in particular. However, our understanding of the roles of multiple Gβγ binding sites on Kir3 channels is still rudimentary. We discuss potential roles for Gβγ in channel assembly and trafficking in addition to their known role in cellular signaling.
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