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Postpubertal nonfamilial cherubism and teeth transposition.

Bora Ozan¹, Mehtap Muğlali, Peruze Celenk

¹Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayıs University, Samsun, Turkey. bora.ozan@hotmail.com

The Journal of Craniofacial Surgery

|September 22, 2010

Summary

Cherubism, a rare fibro-osseous disease, causes painless jaw enlargement. This case highlights a nonfamilial form in a postpubertal patient with dental implications.

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Area of Science:

Genetics and Pathology

Background:

Cherubism is a rare, autosomal-dominant, nonneoplastic, fibro-osseous disorder.
It involves the replacement of normal bone with fibrous tissue and immature bone, primarily affecting the jaws.

Observation:

This article details a rare, nonfamilial case of cherubism presenting in a postpubertal individual.
Clinical presentation included bilateral, painless jaw enlargement, most severe in the mandible, and associated dental abnormalities.
Radiographic examination revealed multiple radiolucencies.

Findings:

Histopathological analysis showed characteristic features of cherubism, including multinucleated giant cells within a fibrous connective tissue stroma.
The nonfamilial, postpubertal presentation and its impact on dentition were key findings.

Implications:

Understanding the varied presentations of cherubism is crucial for accurate diagnosis and management.
This case underscores the importance of considering cherubism in nonfamilial, postpubertal patients with jaw lesions and dental anomalies.