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Updated: Jun 8, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Two cases of periocular cutaneous angiosarcoma.

Damrong Wiwatwongwana¹, Valerie A White, Peter J Dolman

¹Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Ophthalmic Plastic and Reconstructive Surgery

|September 22, 2010

Summary

Angiosarcoma rarely affects the eyelid, with only 10 cases reported to date. Despite aggressive treatment, these eyelid angiosarcomas showed aggressive behavior and poor prognoses in the reported cases.

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Area of Science:

Oncology
Ophthalmology
Dermatology

Background:

Angiosarcoma is a rare vascular malignancy.
Eyelid involvement is exceptionally uncommon, with only 8 prior documented cases.
This study presents two additional cases of eyelid angiosarcoma.

Observation:

One case was a primary eyelid angiosarcoma, while the second was a recurrence.
Both lesions were deceptively inconspicuous.
The actual extent of the tumors during micrographic surgery was significantly underestimated based on initial appearance.

Findings:

Despite achieving wide surgical margins, adjuvant radiotherapy, and chemotherapy, aggressive tumor behavior was observed.
One patient succumbed to distant metastasis.

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Last Updated: Jun 8, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

The second patient experienced distant cutaneous recurrences within a year of treatment.

Implications:

Eyelid angiosarcoma, though rare, presents a significant clinical challenge due to its potential for aggressive behavior and recurrence.
Early and accurate diagnosis is crucial, despite the inconspicuous nature of the lesions.
Multidisciplinary treatment approaches are necessary, but the prognosis remains guarded, highlighting the need for further research into effective therapeutic strategies.