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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Sarcoma botyroides of the cervix in a HIV positive 45-year-old woman: a case report
D C D Anyiam1, C O Ukah, I V Onyiaorah
1Department of Histopathology, NAUTH, Nnewi. dananyiam@yahoo.com
Insights
Sarcoma botyroides, a rare rhabdomyosarcoma, typically affects children but can occur in adults. This case highlights a cervical sarcoma botyroides in a 45-year-old HIV-positive woman, emphasizing the need for vigilance in diagnosing cervical masses.
Area of Science:
- Oncology
- Pathology
- Gynecology
Background:
- Embryonal rhabdomyosarcomas, or sarcoma botyroides, are rare pediatric malignancies originating from skeletal muscle progenitors.
- While most common in children under 10, sarcoma botyroides can occur at any age, with peaks in early childhood and adolescence.
- This tumor is exceptionally rare in adult women's reproductive tracts, particularly those over 40.
Unlabelled:
Embryonal rhabdomyosarcomas (Sarcoma botyroides) are malignancies of connective tissue with abnormal cells which are thought to arise from skeletal muscle progenitors. It is a rare childhood malignant solid tumour and occurs in children mostly less than 10 years. It can occur at any age but two commonest peaks are 1-5 years (when approximately 66.6% occur) and 15-19 years accounting for the rest. Sarcoma botyroides which usually occurs in the vagina in childhood is rare in the female reproductive tract of adult women especially those over the age of 40. We report here a case of a 45-year-old HIV-positive woman who presented with profuse bleeding from the vagina with severe anaemia. Macroscopically, a cauliflower polypoid growth was seen protruding from the cervix into the vagina. Histopathological studies confirmed a diagnosis of sarcoma botyroides.
Conclusion:
The need for a high index of suspicion of sarcoma botyroides of the cervix must be borne in mind when making a diagnosis on all cervical polypoidal masses. Also the importance of looking out for lesions and malignancies on all HIV positive patients cannot be over-emphasized.
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