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Published on: November 27, 2014
Xenotropic virus and autoimmunity in NZB mice
Arthritis and Rheumatism
|June 1, 1978
Summary
High xenotropic virus expression in NZB mice is controlled by two genes, Nzv-1 and Nzv-2. Viral phenotypes in offspring could be separated from autoimmune disease development, suggesting distinct genetic influences.
Area of Science:
- Virology
- Immunology
- Genetics
Background:
- NZB mice exhibit high xenotropic virus expression.
- Genetic factors influence viral expression and autoimmune disease development.
Purpose of the Study:
- To investigate the genetic basis of xenotropic virus expression in NZB mice.
- To determine the relationship between viral phenotypes and autoimmune disease markers.
Main Methods:
- Cross-breeding NZB mice with SWR mice.
- Analyzing progeny for viral expression levels (high, low, negative).
- Assessing autoantibodies and immune complex nephritis.
Main Results:
- Viral expression segregated into three phenotypes: high, low, and virus-negative.
- Viral phenotypes were independent of autoantibodies and nephritis.
- Nephritis could occur without detectable viral antigen deposits in glomeruli.
Conclusions:
- Two autosomal dominant loci (Nzv-1 and Nzv-2) control xenotropic virus expression.
- Viral expression and autoimmune disease pathogenesis are genetically distinct in this model.
- Further research is needed to elucidate the mechanisms linking viral expression and autoimmune disease.
