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Incidence and prevalence of juvenile idiopathic arthritis in Catalonia (Spain)
C Modesto1, J Antón, B Rodriguez
1Department of Rheumatology, University Hospital Vall d'Hebron, Barcelona, Spain. cmodesto@vhebron.net
Insights
This study determined the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Catalonia, finding lower rates than in Nordic countries. Oligoarthritis was the most common JIA subtype in children.
Area of Science:
- Pediatric Rheumatology
- Epidemiology
- Public Health
Background:
- Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease affecting children.
- Understanding the epidemiology of JIA is crucial for resource allocation and public health strategies.
- Previous epidemiological data for JIA in Catalonia were limited.
Purpose of the Study:
- To determine the incidence and prevalence of JIA in Catalonia, Spain.
- To analyze JIA subtypes based on established classification criteria.
- To compare epidemiological data with other European regions.
Main Methods:
- A prospective, population-based study conducted from 2004-2006 in Catalonia.
- Educational programs for pediatricians to improve JIA diagnosis and reporting.
- Application of International League of Associations for Rheumatology (ILAR) classification criteria.
- Prospective and retrospective data collection for incidence and prevalence calculation.
Main Results:
- The mean annual incidence of JIA was 6.9/10⁵ children (<16 years), with higher rates in girls.
- The prevalence of JIA was 39.7/10⁵ children (<16 years) as of October 2006.
- Oligoarthritis was the most frequent subtype, particularly in older girls; enthesitis-related arthritis was more common in older boys.
- Most diagnoses (70%) were made before age 7.
Conclusions:
- This is the first population-based epidemiological study of JIA in Catalonia.
- JIA incidence and prevalence rates in Catalonia are lower than reported in Nordic European countries.
- Oligoarthritis is the predominant subtype of JIA in this region.
Objective:
To ascertain the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Catalonia (autonomous region in northeast Spain), examined according to the currently established disease subtypes.
Methods:
Before initiating the study, we conducted an educational programme on paediatric rheumatology, addressed to all general paediatricians in Catalonia. A 2-year (2004-2006), prospective, population-based study was then carried out to determine the incidence of JIA. Prospective and retrospective data retrieval was performed to calculate prevalence. The International League of Associations for Rheumatology (ILAR, Edmonton revision) classification criteria were applied.
Results:
Over the study period, 145 new cases of JIA were diagnosed. The mean annual incidence was 6.9/10⁵ children aged less than 16 years (range 5.8-8.1 years; 9.0 years for girls and 4.8 years for boys). On separate analysis of patients ≤ 6 and > 6 years, the distribution in younger children was found to be similar for both girls and boys, whereas in older children, most girls belonged to the oligoarthritis and polyarthritis subgroups, and boys to the enthesitis-related arthritis and undifferentiated subgroups. The calculated prevalence of JIA (31 October 2006) was 39.7 (36.1-43.7)/10⁵ children younger than 16. The relative risk of girls having JIA was 2.1 [95% confidence interval (CI) 1.7-2.7, p < 0.001]. In 70% of patients, the diagnosis was established before the age of 7. Subgroup distribution of prevalent cases mirrored that of incident cases.
Conclusion:
This is the first population-based study on the epidemiology of JIA in Catalonia. Incidence and prevalence rates are lower than those reported for several areas in Nordic countries of Europe. Oligoarthritis was the most common subtype.
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