Lipid and lipoprotein secretion following portacaval shunt in swine

Lipid and lipoprotein secretion were studied over 24 h in normal and portacaval shunted (PCS) fasting miniature swine after an infusion of Triton WR-1339 and [3H]amino acid mixture. The plasma triglyceride secretion rate and the secretion of triglyceride, total cholesterol and protein in the very low density lipoprotein fraction (VLDL) were linear for about 9 h after Triton. No net catabolism of the VLDL appeared to take place over the 24 h. Due to large variation, differences in the absolute secretion rates of plasma triglyceride and of the VLDL constituents could not be shown. However, the secretion of VLDL cholesterol in the PCS group appeared to be lower than that of the sham group when corrected for metabolic body size and plasma volume.