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Related Concept Videos

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Action Potentials01:41

Action Potentials

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Related Experiment Video

Updated: Jun 8, 2026

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
09:41

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

The myelin brake: when enough is enough.

Wendy B Macklin1

  • 1Department of Cell and Developmental Biology, University of Colorado Denver Health Science Center, Aurora, CO 80045, USA. wendy.macklin@ucdenver.edu

Science Signaling
|September 23, 2010
PubMed
Summary

Dlg1 abundance regulates myelination termination in Schwann cells. This finding reveals a key signal that stops the active production of myelin in the peripheral nervous system.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Myelination, essential for nerve function, is orchestrated by glial cells like Schwann cells (peripheral nervous system) and oligodendrocytes (central nervous system).
  • Axon-glia interactions are critical for regulating myelination, with known signaling pathways controlling myelin production.
  • However, the signals that terminate myelination remain poorly understood.

Purpose of the Study:

  • To identify the molecular signals that determine when Schwann cells cease active myelination.
  • To elucidate the role of Discs large homolog 1 (Dlg1) in regulating the termination of myelination.

Main Methods:

  • Investigated the role of Dlg1 in Schwann cell myelination.
  • Analyzed the correlation between Dlg1 abundance and the cessation of myelin production in the peripheral nervous system.

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Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation
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Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation

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Last Updated: Jun 8, 2026

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
09:41

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

Coherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain Slices
04:08

Coherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain Slices

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Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation
08:34

Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation

Published on: June 17, 2025

Main Results:

  • Demonstrated that the abundance of Dlg1 in Schwann cells is a critical factor in halting active myelination.
  • Higher levels of Dlg1 correlate with the termination of myelin production.

Conclusions:

  • Dlg1 acts as a key regulator, signaling the end of active myelination in Schwann cells.
  • Understanding Dlg1's role provides crucial insights into the control mechanisms of peripheral nervous system development and repair.