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Updated: Jun 8, 2026
Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
Published on: July 14, 2010
Anesthetics promoting in vitro AβPP metabolism and amyloid-β toxicity
Barbara Eckel1, Manfred Blobner, Gerhard Rammes
1Klinik für Anästhesiologie, Technische Universität München, Germany. b.eckel@lrz.tum.de
Abstract:
At present, more than 35 million people worldwide have Alzheimer's disease (AD). With increasing incidence and a growing number of aged patients undergoing surgery, the relevance of a possible interaction between anesthetics and AD is growing as well. Below, we review in vitro studies investigating the effects of anesthetics on the metabolism of amyloid precursor protein and its metabolite amyloid-β.
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