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Surveillance of severe invasive group G streptococcal infections in Japan during 2002-2008

Tadayoshi Ikebe1, Yuuko Oguro, Kikuyo Ogata

  • 1Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo 162-8640, Japan. tdikebe@nih.go.jp

Japanese Journal of Infectious Diseases
|September 23, 2010
PubMed

Insights

Genotypes of Group G Streptococcus causing severe invasive infections in Japan have changed. New strains emerged between 2002-2008, while some earlier strains disappeared, indicating evolving pathogens.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Group G Streptococcus (GGS) is a significant cause of severe invasive infections.
  • Understanding the genotypic diversity and prevalence of GGS is crucial for public health surveillance.

Purpose of the Study:

  • To compare the genotypic prevalence of GGS strains causing severe invasive infections in Japan between two distinct periods: 1995-2001 and 2002-2008.
  • To identify shifts in the dominant GGS genotypes over time.

Main Methods:

  • Retrospective analysis of GGS strains isolated from patients with severe invasive infections.
  • Genotyping of GGS strains to determine their genetic profiles.
  • Comparative analysis of genotype prevalence between the two study periods.

Main Results:

  • Several GGS genotypes (stg485, stg6792, stc36, stg6, and stg652) were identified in both the 1995-2001 and 2002-2008 periods.
  • New GGS genotypes emerged in the 2002-2008 period.
  • Some genotypes prevalent in 1995-2001 were no longer detected in the later period.

Conclusions:

  • The genotypic landscape of Group G Streptococcus causing severe invasive infections in Japan has evolved between 1995-2008.
  • These findings highlight the dynamic nature of bacterial populations and the emergence of new strains, necessitating ongoing surveillance and adaptation of treatment strategies.

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