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[Crossed cerebellar diaschisis after brainstem infarction]
Rinsho Shinkeigaku = Clinical Neurology
|November 1, 1990
Summary
Brainstem lesions can cause Crossed Cerebellar Diaschisis (CCD), a condition of reduced cerebellar metabolism. This study demonstrates CCD resulting from transneuronal deactivation following a midbrain lesion.
Area of Science:
- Neuroscience
- Neurology
- Cerebrovascular Diseases
Background:
- Crossed Cerebellar Diaschisis (CCD) is metabolic depression in the cerebellum contralateral to a supratentorial stroke.
- It is understood as transneuronal deactivation due to loss of excitatory afferent inputs.
- The corticopontocerebellar pathway is considered crucial for inducing CCD.
Observation:
- A case study of an 80-year-old female with sudden left-sided hemiparesis.
- Initial CT scans revealed no stroke lesion.
- MRI identified a lesion in the right midbrain (peduncle and tegmentum).
Findings:
- Single photon emission computed tomography (SPECT) using IMP showed decreased blood flow in the left cerebellar hemisphere.
- This pattern confirmed the presence of Crossed Cerebellar Diaschisis (CCD).
- The findings suggest a brainstem lesion can induce CCD.
Implications:
- This case supports the hypothesis that lesions anywhere in the corticopontocerebellar pathway can induce CCD.
- It highlights that brainstem lesions, specifically in the midbrain, can lead to transneuronal deactivation and CCD.
- Further research into cerebrocerebellar pathways and brainstem stroke implications is warranted.