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Gas-phase isolation of diethyl guanosine 5'-monophosphate and its conformational assignment

Hiroya Asami1, Masaki Tsukamoto, Yoshihiro Hayakawa

  • 1Graduate School of Arts and Sciences, Yokohama City University, 22-2 Seto, Kanazawa, Yokohama 236-0027, Japan.

Physical Chemistry Chemical Physics : PCCP
|September 23, 2010
PubMed

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins, also known...