Related Experiment Video
Updated: Jun 8, 2026
11:19
Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
Published on: October 9, 2016
Diffuse large B cell lymphoma in hyper-IgE syndrome due to STAT3 mutation
Attila Kumánovics1, Sherrie L Perkins, Heather Gilbert
1Department of Pathology, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
Journal of Clinical Immunology
|September 23, 2010
Summary
Job
Area of Science:
- Immunology
- Genetics
- Oncology
Background:
- Job syndrome (hyper-immunoglobulinemia E syndrome) is an autosomal dominant primary immunodeficiency.
- STAT3 gene mutations are identified in most autosomal dominant cases, enabling molecular diagnosis.
- Immunodeficiencies, including hyper-IgE syndrome, increase malignancy risk, particularly lymphomas.
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