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A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

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Imaging modalities to assess structural birth defects in mutant mouse models.

Kimimasa Tobita¹, Xiaoqin Liu, Cecilia W Lo

¹Department of Developmental Biology, University of Pittsburgh, Pennsylvania 15224, USA. kit3@pitt.edu

Birth Defects Research. Part C, Embryo Today : Reviews

|September 23, 2010

Summary

Advanced imaging techniques like ultrasound biomicroscopy and micro-MRI enable rapid phenotyping of structural birth defects (SBDs) in animal models. These methods allow detailed, noninvasive assessment of fetal development and detection of various SBDs.

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Area of Science:

Developmental Biology
Medical Imaging
Toxicology

Background:

Traditional assessment of structural birth defects (SBDs) in animal models involves invasive necropsy and histology.
These methods are time-consuming and do not allow for longitudinal studies of fetal development.

Purpose of the Study:

To review the application of advanced imaging technologies for the rapid phenotyping of SBDs in rodent embryos and fetuses.
To highlight the utility of these technologies in detecting a wide range of structural abnormalities.

Main Methods:

Review of recent advances in imaging technologies including ultra-high frequency ultrasound biomicroscopy, optical coherence tomography, micro-CT, and micro-MRI.
Discussion of the application of these modalities for noninvasive, in utero assessment of fetal anatomy and cardiovascular function.

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Last Updated: Jun 8, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

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Published on: December 16, 2022

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Main Results:

Advanced imaging modalities permit detailed assessment of organ and tissue structure in developing rodent embryos and fetuses.
Ultrasound biomicroscopy allows for noninvasive, longitudinal tracking of fetal development and cardiovascular assessment.
These technologies facilitate the detection of a broad spectrum of SBDs.

Conclusions:

State-of-the-art imaging technologies offer efficient and detailed methods for SBD phenotyping in preclinical research.
These noninvasive techniques can replace or supplement traditional methods, enabling longitudinal studies and early detection of developmental abnormalities.