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Metronidazole-induced pancreatitis.
E O'Halloran1, A Hogan, K Mealy
1Department of Surgery, Wexford General Hospital, Wexford, Ireland. ohalloranemily@gmail.com
HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
|September 24, 2010
Summary
Metronidazole, an antibiotic, can cause acute pancreatitis, a rare but serious side effect. This case report highlights the importance of considering drug-induced pancreatitis for prompt diagnosis and recovery.
Area of Science:
- Gastroenterology
- Pharmacology
- Internal Medicine
Background:
- Drug-induced pancreatitis is a rare condition, accounting for approximately 2% of all pancreatitis cases.
- Metronidazole is an antibiotic commonly used to treat various infections.
Observation:
- A 25-year-old female presented with acute epigastric pain radiating to the back, nausea, and vomiting.
- Symptoms began after receiving the third dose of Metronidazole for a periodontal abscess.
- The patient had a similar episode 10 months prior, with no other identifiable causes.
Findings:
- Metronidazole was identified as the likely causative agent for acute pancreatitis.
- The patient's symptoms resolved rapidly upon discontinuation of Metronidazole.
- This represents the eighth reported case of Metronidazole-induced pancreatitis, all occurring in females.
Implications:
- Early recognition and drug cessation are crucial for successful management of Metronidazole-induced pancreatitis.
- Further research into the exact mechanism of Metronidazole-induced pancreatitis is warranted.
- This case underscores the importance of considering medication side effects in the differential diagnosis of acute pancreatitis.
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