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Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
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Published on: March 12, 2015

A highly sensitive viscosity probe based on ferrocene-BODIPY dyads.

Xiaodong Yin1, Yongjun Li, Yulan Zhu

  • 1Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Organic Solids, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.

Dalton Transactions (Cambridge, England : 2003)
|September 24, 2010
PubMed
Summary

Two novel ferrocene-BODIPY molecules were synthesized and show potential as viscosity probes. Their emission properties are tunable by molecular design and increase with solvent viscosity, indicating molecular rotor behavior.

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Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
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Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
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Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
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Published on: February 9, 2012

Area of Science:

  • Materials Science
  • Supramolecular Chemistry
  • Photochemistry

Background:

  • Ferrocene and BODIPY (Boron-dipyrromethene) are versatile building blocks in materials science.
  • Molecular rotors are molecules whose rotational motion is sensitive to their environment.
  • Tuning molecular structure is key to controlling optical properties.

Purpose of the Study:

  • To synthesize and characterize novel ferrocene-BODIPY hybrid molecules.
  • To investigate the photophysical properties and environmental sensitivity of these molecules.
  • To explore their potential application as viscosity probes.

Main Methods:

  • Synthesis and characterization of FcEB and FcB molecules.
  • X-ray diffraction analysis to determine crystal packing.
  • Spectroscopic measurements (UV-Vis absorption, fluorescence emission) in solvents of varying viscosity.

Main Results:

  • Successful synthesis and characterization of two novel ferrocene-BODIPY compounds, FcEB and FcB.
  • X-ray diffraction revealed an "interlock" packing mode in both molecules.
  • FcEB demonstrated molecular rotor behavior, with significantly enhanced quantum yield and emission intensity in high-viscosity solvents.

Conclusions:

  • The synthesized ferrocene-BODIPY molecules exhibit tunable structure-optical properties.
  • FcEB functions as an effective molecular rotor sensitive to solvent viscosity.
  • These findings highlight the potential of FcEB as a viscosity probe for biological systems.