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Pindolol inhibits the development of hypoxic pulmonary vasoconstriction
T Takashio1, H Yamashita, S Onodera
1First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan.
European Journal of Pharmacology
|December 4, 1990
Abstract:
We examined the effects of beta-adrenoceptor antagonists, propranolol and pindolol, on hypoxic pulmonary vasoconstriction using isolated, blood-perfused dog lung lobes. Pindolol markedly inhibited the development of hypoxic pulmonary vasoconstriction, whereas propranolol had no effect. The different role of the drugs on hypoxic pulmonary vasoconstriction is discussed.