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Vascular calcifications and renal osteodystrophy in chronic hemodialysis patients: what is the relationship between

Diana Moldovan1, Ioan Moldovan, Crina Rusu

  • 1Mihai Manasia Nephrology and Dialysis Clinic Cluj-Napoca, University of Medicine and Pharmacy Cluj-Napoca, Nephrology Clinic 3-5 Clinics Street, 400006 Cluj-Napoca, Romania. Diana.Moldovan@umfcluj.ro

International Urology and Nephrology
|September 24, 2010
PubMed

Insights

Vascular calcifications (VCs) and renal osteodystrophy (ROD) are common in hemodialysis patients. ROD, male gender, and calcium salt treatment are risk factors for developing VCs, suggesting a link between bone and artery disease.

Area of Science:

  • Nephrology
  • Cardiology
  • Bone Metabolism

Background:

  • Vascular calcifications (VCs) and renal osteodystrophy (ROD) are prevalent complications in hemodialysis (HD) patients.
  • These conditions significantly contribute to morbidity and mortality in this population.
  • A potential pathogenic link between VCs and ROD remains debated.

Purpose of the Study:

  • To investigate the relationship between VCs and ROD in chronic HD patients.
  • To evaluate the prevalence of VCs and ROD.
  • To identify clinical and biochemical factors associated with VCs in HD patients.

Main Methods:

  • Radiological assessment of VCs and ROD using hand and pelvis bone radiographs in 81 chronic HD patients.
  • Calculation of a vascular calcification (VC) score.
  • Correlation and regression analyses to determine associations between VCs, ROD, and clinical/biochemical parameters.

Main Results:

  • A significant association was found between radiological signs of ROD and VCs (P = 0.019).
  • Patients with ROD exhibited a higher mean VC score (P = 0.02).
  • VC score correlated with serum calcium, phosphorus, iPTH, CaxP product, and inversely with albumin. ROD, male gender, and calcium salt treatment predicted VCs.

Conclusions:

  • A pathogenic link between bone disease (ROD) and arterial disease (VCs) is suggested in chronic HD patients.
  • Both VCs and ROD are highly prevalent in this cohort.
  • ROD, male gender, and calcium salt treatment are identified as risk factors for VCs.
Abstract

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