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A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
[Pulmonary hypertension due to left heart disease: recommendations of the Cologne Consensus Conference 2010]
S Rosenkranz1, D Bonderman, M Buerke
1Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Köln. stephan.rosenkranz@uk-koeln.de
Insights
German guidelines for pulmonary hypertension (PH) need updates, especially for PH due to left heart disease. This commentary addresses practical issues and emerging data for better PH patient care.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Clinical Guidelines
Background:
- European 2009 Guidelines for Pulmonary Hypertension (PH) adopted in Germany.
- Guidelines offer limited detail on PH due to left heart disease, despite its frequency.
- Concerns exist regarding off-label use of pulmonary arterial hypertension (PAH) treatments for PH in left heart disease.
Framework:
- The German adaptation of European PH guidelines requires specific considerations and updates.
- A Consensus Conference in June 2010 addressed practical and controversial issues in implementing these guidelines in Germany.
- Working groups, including one focused on PH due to left heart disease, were established to refine recommendations.
Implementation:
- This commentary summarizes the results and recommendations from the working group on PH due to left heart disease.
- It addresses the practical challenges and controversies surrounding the application of European PH guidelines in Germany.
- The need for a detailed commentary and potential updates to the guidelines is emphasized.
Implications:
- Clarifies the application of European PH guidelines for PH due to left heart disease in Germany.
- Provides recommendations for managing this frequent and significant comorbidity.
- Highlights the necessity for ongoing research and guideline refinement in PH management.
Abstract:
The 2009 European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension have been adopted for Germany. While the guidelines contain detailed recommendations regarding pulmonary arterial hypertension (PAH), they contain only a relatively short paragraph on other, much more frequent forms of PH such as PH due to left heart disease. Despite the lack of data, targeted PAH treatments are increasingly being used for PH associated with left heart disease. This development is of concern. On the other hand, PH is a frequent problem that is highly relevant for morbidity and mortality in patients with left heart disease, so that it may be speculated whether selected patients may benefit from targeted PH therapy. It that sense, the practical implementation of the European Guidelines in Germany requires the consideration of several specific issues and already existing novel data. This requires a detailed commentary to the guidelines, and in some aspects an update already appears necessary. In June 2010, a Consensus Conference organized by the PH working groups of the German Society of Cardiology (DGK), the German Society of Respiratory Medicine (DGP) and the German Society of Pediatric Cardiology (DGPK) was held in Cologne, Germany. This conference aimed to solve practical and controversial issues surrounding the implementation of the European Guidelines in Germany. To this end, a number of working groups was initiated, one of which was specifically dedicated to PH due to left heart disease. This commentary summarizes the results and recommendations of this working group.
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