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Articular cartilage calcification in osteoarthritis: insights into crystal-induced stress

Hang-Korng Ea1, Christelle Nguyen, Dominique Bazin

  • 1INSERM UMR-S 606, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, PRES Sorbonne Paris-Cité, and Université Paris Denis Diderot, Paris, France. korngea@yahoo.fr

Arthritis and Rheumatism
|September 24, 2010
PubMed
Abstract

No abstract available in PubMed .

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...